Pac-Man · Year: 1980
Effects: Renders the consumer temporarily capable of eating ghosts. Here’s an eternal question: are the pellets Pac-Man relentlessly consumes supposed to be drugs or food? The smaller ones are food, maybe, but the power pills off in the corners have such a profound effect on the yellow fellow that it’s hard not to wonder about them.
If you define them as drugs, which seems like a pretty safe assumption, this would be the first pioneering appearance of drugs as power-ups in games, a tradition that would be carried on by more titles than can reliably be counted.
And the list goes on…